西地那非对男性不育的影响:20年来发生了什么变化?_高血压患者可以吃万艾可吗

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摘要

西地那非对男性不育的影响:20年来发生了什么变化? Sildenafil’s impact on male infertility: what has changed in 20 years? Int J Impot Res. 2019 Mar;31(2):71-73. doi: 10.1038/s41443-018-0067-x. Epub 2019 Mar 5. Scherzer ND, Le TV, Hellstrom WJG.

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内容提要 勃起功能障碍(Erectile Dysfunction, ED)是一种较为常见的男性疾病。随着现代生活节奏的加快、生活压力的增大,该病的发病率仍在逐年增加。据统计全球约1.5亿人患ED,到2025年ED患者将超过3亿人。国内与国外《阴茎勃起功能障碍诊断与治疗指南》推荐

西地那非对男性不育的影响:20年来发生了什么变化?

Sildenafil's impact on male infertility: what has changed in 20 years?

Int J Impot Res. 2019 Mar;31(2):71-73. doi: 10.1038/s41443-018-0067-x. Epub 2019 Mar 5.

Scherzer ND, Le TV, Hellstrom WJG.


西地那非对男性不育的影响:20年来发生了什么变化?_高血压患者可以吃万艾可吗

摘要

在过去的20年里,西地那非在性医学领域产生了巨大的影响。磷酸二酯酶-5 (PDE5)抑制剂不仅改善了勃起功能障碍(ED)的治疗,还间接促进了男性因素不育的治疗。利用PubMed1998 - 2018年间关于西地那非和男性不育的文献进行了综述。大量研究表明,西地那非治疗ED的安全性和有效性。西地那非不会改变精液参数,事实上,可能会对精液参数产生积极影响。西地那非对治疗不孕症的心理应激性ED有一定的帮助。西地那非改善了ED的治疗,可能对精液参数有好处。这有助于改善男性因素的不育,并促成了成千上万的怀孕。


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Abstract

Nintedanib加西地那非治疗特发性肺纤维化患者

SCI 26 September 2018 Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis Kolb Martin,Raghu Ganesh,Wells Athol U et al. Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis.[J] .N. Engl. J. Med., 2

Sildenafil has had a dramatic influence on the field of sexual medicine over the past 20 years. Not only have phosphodiesterase-5 (PDE5) inhibitors improved the treatment of erectile dysfunction (ED), they have indirectly contributed to the treatment of male factor infertility. A review of the literature between 1998 - 2018 was performed using PubMed with regards to sildenafil and male infertility. Numerous studies have demonstrated sildenafil's safety and efficacy for treating ED. Sildenafil does not alter semen parameters, and, in fact, may positively affect semen parameters. Sildenafil is helpful for treating ED caused by the psychological stress of infertility treatments. Sildenafil has improved the treatment of ED and may have a benefit on semen parameters. This has aided in the management of male factor infertility, and has contributed to hundreds of thousands of pregnancies that would have been more difficult, as it was before its advent.

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